2.3 Incomplete regeneration:

The new tissue is not the same as the tissue that was lost. After the repair process has been completed, there is a loss in the structure or function of the injured tissue. In this type of repair, it is common that granulation tissue (stromal connective tissue) proliferates to fill the defect created by the necrotic cells. The necrotic cells are then replaced by scar tissue. This type of repair is common after pathological tissue injury.
The necrotic parenchymal cells have a poor ability to regenerate. Examples of parenchymal cells with little or no ability to regenerate are muscle cells of the heart (myocardium) and specialized cells of the nervous system (neurons).
②The damaged area is very large and the stromal framework of the injured tissue is not well preserved.